Innovative Microchip Solutions

Technical advantage

Neatbio Biotechnology Co., founded in 2018, specializes in semiconductor manufacturing, biochemistry, and biosensing. The company is renowned for developing cutting-edge micro-electrode array chips tailored for cell transfection and enrichment. These advanced chips are crafted using specialized manufacturing foundries, which involve high costs and limited material choices due to their intricate design rules and micro-machining processes.

Most micro/nano electrode arrays are integrated with CMOS technology through MEMS (Micro-Electro-Mechanical Systems) or NEMS (Nano-Electro-Mechanical Systems). The development of various micro-sensors and electrodes often requires specialized manufacturing foundries, which involve high costs and limited material choices, design rules, and fabrication processes. These limitations can restrict the production and innovation of new technologies. However, standard CMOS processes offer a viable alternative for producing nano-structures with simple nano configurations or three-dimensional (3D) electrodes, providing a cost-effective and flexible solution for manufacturing advanced sensors and electrodes.

Neatbio Co. employs standard CMOS technology to fabricate sensors with both simple nano-structures and sophisticated three-dimensional (3D) designs. Our patented technology enables precise cell transfection and enrichment. Each micro-electrode features a tip diameter of 40 nm and a 70 nm gap between electrodes. When a voltage is applied, it generates a strong, localized electric field around the single cell, allowing for precise control and positioning.

The varying electric field strength creates pores on the cell membrane, facilitating either single-cell transfection or lysis. Post electroporation, the cell membrane re-seals, allowing biomolecules to enter without compromising cell viability. This technique ensures efficient delivery of biomolecules while preserving cell integrity through carefully managed electric fields and pressurized flow.

Cutting-Edge Technology

Expert Technical Team

Our patented 3D nano-chip technology provides precise non-contact dielectrophoresis, which enhances cell viability and drug delivery, ensures high transfection efficiency, and reduces Joule heating, sample contamination, and toxicity. This makes it highly suitable for advanced biochemical applications.

• Precise Non-Contact Dielectrophoresis: Enables manipulation of cells and particles without physical contact, reducing the risk of contamination and mechanical damage.

• Enhanced Cell Viability and Drug Delivery: Maintains high cell viability during processes and facilitates efficient drug delivery.

• High Transfection Efficiency: Achieves effective and efficient transfection of cells, critical for genetic studies and therapeutic applications.

• Lower Joule Heating Effect: Minimizes heating during electrical manipulations, preserving cell health.

• Reduced Sample Contamination: Non-contact method ensures samples remain uncontaminated.

• Lower Toxicity: Reduces toxic effects compared to traditional methods.

Electroporation enhances cell membrane permeability through an external electric field, creating transient hydrophilic pores that facilitate the transport of biomolecules. This technique is pivotal for cell manipulation and molecular delivery, with advanced technologies improving its efficiency and reducing adverse effects.

Get In Touch

Reach out to our technical team for inquiries about our innovative microelectrode array chip technology.